Biophysics 2020 - Lecture 12

Repeating folding units and cold denaturation from Lucie's lecture last week. Drug design. The various phases of designing and testing new drugs in pharma. Docking consists of scoring and screening, with highly simplified energy (scoring) functions to make it fast enough. Ligand-based drug design and fragment-based drug design. Lipinsky's rule of five. The (risky) economics of drug development. A case study of some very recent coronavirus work.